Glandular Ulcer Treatment Bundle

Regime: Sucralfate is a multiple daily dose medication. Length of administration depends on the condition, severity and type of ulcer being treated. The following dosage example is based on a horse weighing 450kg (990lb)

Non Glandular - Squamous Ulcers

• Loading or active treatment dose:
  • Week 1 - 4: Omeprazole (AbPrazole™) - 2 x sachets, once per day x 28 days.
  • Week 1 - 3: Sucralfate (AbSucralfate™) - 3 x sachets, two times per day for up to 28 days

• Maintenance or preventative dose:
  • Omeprazole: Gradually reduce to 1 x sachet, once per day.
  • Sucralfate: Reduce to 2 x sachets, once per day.

Glandular Ulcers

• Loading or active treatment dose:
  • Week 1 - 6*: Omeprazole (AbPrazole™) - 2 x sachets, once per day
  • Week 6 - 8: Omeprazole (AbPrazole™) - 2 x sachets, once per day (if required)
  • Week 1 - 3*: Sucralfate (AbSucralfate™) - 3 x sachets, two times per day
  • Week 3 - 8: Sucralfate (AbSucralfate™) - 2 x sachets, two times per day

• Maintenance or preventative dose:
  • Ongoing: Sucralfate 2 x sachets, two times per day.

Hindgut/Colonic Ulcers - Right Dorsal Colitis

Sucralfate has not been clinically proven to heal colonic ulcers. However, sucralfate is well known as a cytoprotective agent. It binds to GI mucosa, and acts as a "band-aid" to the ulcer crater, offering relief from pain associated with ulcers.

• Recommended dosage:
  • Week 1 - 6: Sucralfate (AbSucralfate™) - 3 x sachets, two times per day
  • Ongoing: Sucralfate (AbSucralfate™) - 2 x sachets, two times per day

AbSucralfate ™

Should be administered 30-60 minutes apart from other medication including Omeprazole (and any other medications).

First dose of the day is best administered before any other food or other medication is given. The morning is when the horses stomach is most likely to be less full.

• Sprinkled onto a small feed (i.e. a few handfuls of moistened chaff).
• Mixed with water and administered via oral syringe.
• Mixed into a paste and smeared onto apples or carrots.

If a dose is missed, give as soon as possible, if next dose is within a few hours of the normal schedule, wait, and give at the regular time. Do not double the dose.

*Long term use: There is minimal absorption of sucralfate. Side effects from long term use are rare.
*Interactions: Sucralfate has been known to bind with other medications, therefore,sucralfate should be administered 30-60 minutes apart from other medication including Omeprazole (and any other medications).
Storage: Store in a cool dry atmosphere away from extreme heat. Store/Transport at 20° to 30°C (68° to 86°F).

AbPrazole ™

Sprinkle granules onto feed. To achieve maximum effectiveness, best not heated, mixed or immersed in water based food, as granules are enteric coated. For fussy eaters mix with molasses or corn syrup then mix with feed, apple or a treat.

Massive overdosage is required to cause problems in other species but the toxic dosage in horses is uncertain. Rats have tolerated oral doses no greater than 40mg/kg (this would be equivalent to ten times of 100% product fed to a horse at one time).

Omeprazole appears to be a safe drug with low associated problems. It is contraindicated in horses hypersensitive to it. Omeprazole may decrease the hepatic clearance of some medications. Omeprazole's safety during pregnancy has not been established.

Omeprazole, like other PPI's, is well tolerated. Nervousness, abnormal heartbeat, muscle pain, weakness, leg cramps and water retention occur infrequently.

Omeprazole appears to be very well tolerated in horses. There may be a possibility of Gastro Intestinal (GI) distress (anorexia, colic, flatulence, diarrhea).

• Do not treat horses intended for human consumption.
• Keep out of reach of children.
• Veterinary use only.

• Store in a cool dry atmosphere away from extreme heat.
• Store/Transport at and 20º to 30ºC ( 68º to 86ºF)